封面專題•COVER STORY 澳大新語•2020 UMAGAZINE 22 7 Interdisciplinary Approach to Cancer Research Cancer is one of the leading causes of death worldwide. In a quest to develop cures for cancer, UM founded the Faculty of Health Sciences (FHS) in 2013. FHS focuses on cancer research and the development of health products, in order to support the local community. FHS cooperates with other UM faculties and institutes, including the Faculty of Science and Technology (FST), the Institute of Chinese Medical Sciences (ICMS), the Institute of Applied Physics and Materials Engineering (IAPME), and the Institute of Microelectronics (IME), in order to carry out interdisciplinary research on cancers commonly found in Macao. Scholars use state‑of‑the‑art technologies, such as microfluidic technology and nanotechnology, to enhance the effectiveness of cancer diagnosis and treatment. To improve the quality of cancer research, UM focuses on tackling key issues in two areas: biomedical mechanisms and biomedical materials. FHS has identified eight research areas, one of them being precision cancer medicine. FHS Dean Prof Deng Chuxia, who is also the director of the Cancer Centre, leads his team to establish a frozen tissue bank and a live cell bank for the most common cancers found in Macao. FHS researchers also study tumour growth, metastasis, recurrence, and drug resistance mechanisms, in order to develop early cancer diagnosis methods, identify cancer driver genes, and screen for high‑efficiency drugs that can kill cancer cells. They also conduct research on carcinogenic mechanisms and preventive treatment for mutant genes of breast cancer, nasopharyngeal cancer, colorectal cancer, liver cancer, and lung cancer. For its part, ICMS carries out innovative research on how traditional Chinese medicine induces necroptosis of cancer cells, and how the natural compounds of traditional Chinese medicine help the immune system fight tumours. In terms of biomedical materials, IME has developed a new digital microfluidic system to assist medical personnel to cultivate single cells and select cancer drugs. IAPME has established a world-class nano-bio-optics research platform, through which it promotes collaboration with the university’s oncology research team, and accelerates the progress of research projects on carbon-point cancer diagnosis and treatment. 跨學科攻關癌症研究 癌症是全球人口死亡主因之一。為攻克 癌症這頑疾，澳大在2013年成立健康科 學學院，重點開展癌症研究和醫療保健 產業研發，以填補澳門在這些領域的空 白。澳大在腫瘤精準醫療領域由零開始 研究工作，結合健康科學學院、科技學 院、中華醫藥研究院、應用物理及材料 工程研究院以及微電子研究院之間的跨 學科研究優勢，融合尖端技術，針對常 見癌症，進行深入的癌症基礎研究，包 括利用先進的微流控技術和納米技術， 提升癌症診療成效。 為提升癌症研究水平，澳大分別從生物 醫學機理和生物醫學材料兩大方向攻 關。健康科學學院訂立八大研究板塊， 其中之一是致力癌症精準醫療研究。其 轄下的癌症中心由鄧初夏院長兼任主 任，帶領團隊致力建立澳門主要腫瘤冷 凍組織庫及活細胞庫，研究腫瘤生長、 轉移、復發及耐藥機制，開發早期診斷 癌症方法，鑒定癌症驅動基因，以及篩 選可殺死癌細胞的高效藥物等；並繼續 針對乳腺癌、鼻咽癌、大腸癌、肝癌和 肺癌等的突變基因，進行更多致癌機理 及預防治療的研究。與此同時，中華醫 藥研究院開拓中藥如何誘導癌細胞程序 性壞死，以及中藥天然化合物助力免疫 系統抵抗腫瘤等創新研究。 在生物醫學材料領域則發揮跨學科研究 的優勢，例如微電子研究院研發了一款 嶄新的數位微流控系統，協助醫療人員 培養單細胞和選擇腫瘤藥物；應用物理
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