COVER STORY•封面專題 2020 UMAGAZINE 22•澳大新語 24 Faculty of Health Sciences Associate Professor Shim Joong Sup has identified Aurora Kinase A as the synthetic lethal partner of ARID1A in colorectal cancer cells. His team was among the first to apply the genetic theory of ‘synthetic lethality’ in the treatment of colorectal cancer. The study suggests that Aurora Kinase A is a precision cancer target for the ARID1A mutant colorectal cancer. This research, which has unveiled a new chapter in cancer treatment, has been published in Nature Communications. 健康科學學院副教授沈仲燮首創性運用遺傳學理論——「合成致死」，發現結腸直 腸癌細胞中的「ARID1A基因」的合成致死搭檔為「Aurora Kinase A蛋白」，並 提出後者能作為ARID1A基因突變引起之結腸直腸癌的靶標。這項研究開啟癌症治 療的新篇章，更獲權威期刊《自然通訊》刊登。 遺傳學理論 在結腸直腸癌治療中的應用 Applying Genetic Theory in Colorectal Cancer Treatment 文/盛惠怡‧圖/編輯部，部分由受訪者提供 Chinese & English Text / Debby Seng ‧ Photo / Editorial Board with some provided by the interviewee
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