封面專題•COVER STORY 澳大新語•2020 UMAGAZINE 22 19 鄭文華教授獲中山醫科大學醫學學士學位、加拿大麥基爾大學藥理學博士學位，2006年中山大學「百人計 劃」引進回國。2015年加入澳大，研究青蒿素系列化合物神經保護及抑制腫瘤生長、轉移，調節腫瘤免疫 等作用及其機制，並對其進行結構改造並篩選更有效的抗腫瘤／神經保護藥物。已發表SCI期刊論文100餘 篇，其中一篇獲選為2012年中國最具影響力的國際學術論文。 青蒿素濃縮液有效抑制癌細胞的生長 Artemisinin concentration effectively inhibits the growth of cancer cells 青蒿素濃縮液有效抑制癌細胞的侵襲 Artemisinin concentration effectively inhibits the invasion of cancer cells 的生存時間。青蒿素衍生物還可殺死 一些耐藥腫瘤或延緩腫瘤耐藥性的形 成，也能增強動物的抗腫瘤免疫功能。 鄭教授表示，以往治療葡萄膜惡性眼 科腫瘤的方法是患眼摘除術，但最近 已有研究發現患眼摘除術效果存疑或 幾乎無效，「病人得了腫瘤，在一兩 年以後會發生肝臟轉移而死亡，死亡 率特高。因此我們最近在中藥中找到 一種有效的成份，並發現它可以抑制 腫瘤的生長。」這項新發現目前正處 於申請專利的程序中。 have established cell and animal models for various tumours, including malignant ophthalmic tumours, and we have found that artemisinin and its derivatives can inhibit the growth and metastasis of tumour cells, and extend the survival time of animals,’ says Prof Zheng. He explains that artemisinin derivatives can also kill some drug-resistant tumours, or delay the development of drug resistance. Moreover, artemisinin derivatives have been shown to enhance tumour immunology in animals. Prof Zheng says that in the past, the main treatment for malignant ophthalmic tumours in the uvea was eye removal surgery, but recent studies have found that the effect of eye removal is doubtful at best, and ineffective at worst. ‘The mortality rate of patients with tumours in the uvea is extremely high because the tumours tend to metastasise to the liver after one or two years. We recently found an effective ingredient in Chinese herbal medicine, which can inhibit the growth of tumours,’ says Prof Zheng. The team has already applied for a patent for the discovery. Prof Zheng Wenhua received a bachelor’s degree in medical sciences from Sun Yat‑sen University of Medical Sciences and a doctoral degree in pharmacology from McGill University, in Canada. In 2006, he returned to China through Sun Yat‑sen University’s 100 Talent Programme. He joined UM in 2015, studying the role and action mechanisms of artemisinin compounds in inhibiting tumour growth and metastasis and in enhancing tumour immunology. He restructured and screened the compounds to find more effective anti‑tumour/neuroprotective agents. He has published over 100 papers in SCI-indexed journals, one of which was selected as one of China’s most influential international academic papers in 2012.
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